CCL4 and TMEM179B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CCL4	TMEM179B
Description		C-C motif chemokine ligand 4	transmembrane protein 179B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleolus Plasma Membrane Integral Component Of Membrane Nuclear Speck Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding	Protein Binding
	Biological Process	Monocyte Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Transcription Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: ACKR2 ARL13B CCL3 CCR1 CCR3 CCR5 CCR8 CNR2 CXCL8 GJA8 GPR152 GPRC5D HRAS MARCHF2 MRM1 PRRG2 SLC10A6 SLC18A1 SLC30A2 SLC30A8 SLC7A1 TAS2R5 TIMMDC1 TMEM14B TMEM179B TMEM31 TMEM86B UNC93A	47 interacting genes: ADIPOQ BTN2A2 C1QL4 C2CD2L C3orf52 CCDC167 CCL3L3 CCL4 CCL4L2 CD68 CLCA4 CLCN7 CLDN1 CLDN6 CTXN3 CYB561 DERL3 ERGIC3 FAM163A FATE1 FCER1G FXYD3 GALNT15 GKN1 GPR151 GUCA2A IGFBP5 KRTAP12-2 KTN1 LRP10 LYG1 MARCHF2 MFSD5 MFSD6 PLN SERP2 SLC1A1 SLC22A1 SLC52A1 STX8 TM4SF19 TMEM14A TMEM236 TMEM237 TMEM242 TMEM47 TRARG1
Entrez ID		6351	374395
HPRD ID		01657	14186
Ensembl ID		ENSG00000275302	ENSG00000185475
Uniprot IDs		P13236	Q7Z7N9
PDB IDs		1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL
Enriched GO Terms of Interacting Partners?
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