RBL2 and TP53BP1

Number of citations of the paper that reports this interaction (PubMedID 9233764)
14

Data Source:
BioGRID (far western blotting)

		RBL2	TP53BP1
Description		RB transcriptional corepressor like 2	tumor protein p53 binding protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome	Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Promoter-specific Chromatin Binding	P53 Binding Damaged DNA Binding Transcription Coregulator Activity Protein Binding Methylated Histone Binding Telomeric DNA Binding Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Modification-dependent Histone Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cell Cycle Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Protein Homooligomerization Cellular Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Antibody level in response to infection ( 25758998) Apolipoprotein A1 levels ( 32203549) Cardiometabolic and hematological traits ( 27668658) Eosinophil counts ( 32888494) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Liver volume ( 34128465) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 27036123)
Interacting Genes		44 interacting genes: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	59 interacting genes: ANKS1A ARAP1 ATM BCL6 BLM BRCA1 BRCA2 C10orf55 CCDC120 CCNB1 CDK1 CHEK1 CRB2 CREB5 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AC4 H2AX H4-16 H4C1 H4C14 HGS IFI16 KAT8 KDM1A KLHDC7B LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16 OXER1 PARP1 PAXIP1 PCNT PITX1 POU6F2 PTEN RAD18 RAD50 RAD51 RBL1 RBL2 RELA SLC6A9 SPAG9 SUMO2 TFDP1 TLX3 TP53 UBAP2 USP28 VAC14
Entrez ID		5934	7158
HPRD ID		01576	05569
Ensembl ID		ENSG00000103479	ENSG00000067369
Uniprot IDs		Q08999	A6NNK5 Q12888
PDB IDs		4XI9 5C1D	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT 6VA5 6VIP
Enriched GO Terms of Interacting Partners?
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