LRRC4C and NTNG1

Number of citations of the paper that reports this interaction (PubMedID 14595443)
73

Data Source:
BioGRID (affinity chromatography technology, pull down, x-ray crystallography)
HPRD (in vivo, in vitro)

		LRRC4C	NTNG1
Description		leucine rich repeat containing 4C	netrin G1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Extracellular Region Plasma Membrane Laminin Complex Anchored Component Of Plasma Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Anchored Component Of Presynaptic Active Zone Membrane
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Synaptic Membrane Adhesion	Axonogenesis Animal Organ Morphogenesis Tissue Development Regulation Of Neuron Projection Development Cell Migration Substrate Adhesion-dependent Cell Spreading Modulation Of Chemical Synaptic Transmission Basement Membrane Assembly Synaptic Membrane Adhesion Regulation Of Neuron Projection Arborization Regulation Of Neuron Migration
Pathways			Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cerebellum cortex volume ( 31530798) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cerebrospinal fluid p-tau levels ( 29274321) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) General risk tolerance (MTAG) ( 30643258) High myopia ( 31816047) Iris color (L* coordinate) ( 30895295) Mastocytosis (KIT D816V positive) ( 33421400) Mosquito bite size ( 28199695) Myopia ( 27182965) Osteoporosis-related phenotypes ( 20548944) Pediatric central nervous system tumors (early onset)(pleiotropy) ( 33226468) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Survival in colorectal cancer ( 26586795) Temperament (bipolar disorder) ( 22365631)	Anorexia nervosa ( 21079607) Blood protein levels ( 30072576 29875488) Body mass index ( 28892062) Falling risk ( 32999390) Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Restless legs syndrome ( 29029846) Sleep end time ( 33075057)
Interacting Genes		29 interacting genes: AGTRAP BDKRB1 BMP10 BRICD5 CLDN19 CLEC1A CLEC4G CMTM5 CREB3L4 DOLK DRAM1 EMP3 GJB2 LEPROTL1 LHFPL5 MIP NTNG1 PGAP2 PLP2 SERTM1 SMIM1 SNAP47 STX5 TRAF6 TWSG1 VEZT VSTM1 WHRN YIPF6	1 interacting genes: LRRC4C
Entrez ID		57689	22854
HPRD ID		12303	16389
Ensembl ID		ENSG00000148948	ENSG00000162631
Uniprot IDs		Q4JIV9 Q4JIW0 Q9HCJ2	B4DKF0 Q5IEC3 Q5IEC8 Q9Y2I2 X5DNW2
PDB IDs		3ZYJ	3ZYJ
Enriched GO Terms of Interacting Partners?
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