CCDC146 and SH3BP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CCDC146	SH3BP1
Description		coiled-coil domain containing 146	SH3 domain binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centriole Cytoskeleton	Phagocytic Cup Intracellular Anatomical Structure Nucleus Cytosol Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding
	Biological Process		Phagocytosis, Engulfment Actin Filament Organization Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway
Pathways			RAC1 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 28892062) Macrovascular complications in type 2 diabetes ( 33430853) Ophthalmic complications in type 2 diabetes ( 33430853) Response to amphetamines ( 22952603)
Interacting Genes		71 interacting genes: AKAP9 BLOC1S2 CBY2 CCDC136 CCDC197 CCNDBP1 CDR2 CDR2L CENPH CEP170P1 CEP44 DTNBP1 FSD2 GAS8 GMNN GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 HSF2BP INSYN1 KIFC3 KRT16 KRT18 KRT19 KRT24 KRT26 KRT27 KRT31 KRT34 KRT38 KRT40 KRT86 LHX3 MAGEA11 MAGEA6 MCC MED4 MIPOL1 MRFAP1 MTUS2 N4BP3 NAP1L2 NECAB2 NINL NUP62 PDE4DIP PLEKHF2 PNMA1 PPP2R3C PROSER3 PSMC6 RINT1 RNF40 RPGRIP1 SH3BP1 SYCE1L TEPSIN TFIP11 THOC7 TNR TPM3 TRAF1 TRIM23 TRIM54 TRIML2 TSC22D4 TXLNA USHBP1 VPS28 VPS52	16 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK NGLY1 POT1 RAC1 RHOA SRC SUN2 SYNJ1 TERF1 TRIP10
Entrez ID		57639	23616
HPRD ID		11150	10227
Ensembl ID		ENSG00000135205	ENSG00000100092
Uniprot IDs		Q8IYE0 Q96MS1	A0A2X0SFX7 Q9Y3L3
PDB IDs			4J9D 4J9F
Enriched GO Terms of Interacting Partners?
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