TAOK1 and DYNC1I1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		TAOK1	DYNC1I1
Description		TAO kinase 1	dynein cytoplasmic 1 intermediate chain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Kinetochore Spindle Pole Nucleus Cytoplasm Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Beta-tubulin Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	MAPK Cascade Microtubule Cytoskeleton Organization DNA Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Mitotic G2 DNA Damage Checkpoint Signaling Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Cytoskeleton Organization Neuron Cellular Homeostasis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Serine/threonine Kinase Activity Execution Phase Of Apoptosis Positive Regulation Of Protein Acetylation	Microtubule-based Movement Transport Along Microtubule Vesicle Transport Along Microtubule
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases
GWAS		Body shape index ( 34021172) Mean platelet volume ( 22139419 24026423 19110211 19820697 32888494 22423221 27863252) Platelet count ( 22139419 29066854 32888494) Red cell distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 33830993 31194737) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: C8orf33 CSNK1E DYNC1I1 GEMIN7 MAP2K3 MARK1 NUFIP2 WT1	39 interacting genes: ANXA7 BICD1 CADM4 CDKN1A DDX19B DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 KLC2 MCC MCM7 NAGK NDUFV2 NPTX2 NUDT21 NUP214 PIN1 RAP1GAP RCC1 RUNDC3B SEM1 SERPINE1 SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP ZKSCAN1
Entrez ID		57551	1780
HPRD ID		15467	04798
Ensembl ID		ENSG00000160551	ENSG00000158560
Uniprot IDs		A0A024QZ70 Q7L7X3	A4D1I7 O14576 Q8N542
PDB IDs
Enriched GO Terms of Interacting Partners?
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