ATP13A1 and ARHGEF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ATP13A1	ARHGEF5
Description		ATPase 13A1	Rho guanine nucleotide exchange factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery
	Molecular Function	ATP Binding ABC-type Manganese Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Transmembrane Protein Dislocase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	Cellular Calcium Ion Homeostasis Protein Transport Ion Transmembrane Transport Manganese Ion Transmembrane Transport Extraction Of Mislocalized Protein From ER Membrane	Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Positive Regulation Of Protein Import
Pathways		Ion transport by P-type ATPases	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 33339817) Toenail selenium levels ( 25343990) White blood cell count ( 32888494)	Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		31 interacting genes: AGTR1 APPBP2 AQP6 ARHGEF5 BUD31 CBARP CXCR2 EBP ELOVL4 FAM209A FFAR2 GLP1R GPR42 KMT2E MANBAL MFSD14B MMD RNASEK SCN3B SLC10A6 SLC16A13 SLC30A2 SLC30A8 SLC35C2 SYPL2 TLCD4 TMBIM6 TMEM14B TMEM237 UNC93A VMA21	29 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 SLU7 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1
Entrez ID		57130	7984
HPRD ID		12501	02932
Ensembl ID		ENSG00000105726	ENSG00000050327
Uniprot IDs		A0A024R7N2 Q9HD20	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?
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