SH3GLB2 and EXOSC1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
5

Data Source:
BioGRID (two hybrid)

		SH3GLB2	EXOSC1
Description		SH3 domain containing GRB2 like, endophilin B2	exosome component 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Cadherin Binding	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process		RRNA Processing
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Serum metabolite concentrations in chronic kidney disease ( 33838163)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		38 interacting genes: CCDC158 CCND3 CDKN2D CNOT7 EFHC1 EXOSC1 EXOSC5 FHL3 FXR1 GAA GADD45G GIT2 GOLGA2 KDM1A KRTAP10-1 KRTAP10-8 KRTAP4-5 KRTAP5-11 KRTAP9-3 LGALS14 LNX2 LSM3 MAGEA1 MORF4L1 NMI NTAQ1 NXF1 OGT PICK1 SH3GLB1 SH3KBP1 SREK1 STX4 TBC1D7 TEX11 TRAF1 TSG101 YES1	31 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC7 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76
Entrez ID		56904	51013
HPRD ID		15334	16223
Ensembl ID		ENSG00000148341	ENSG00000171311
Uniprot IDs		A0A024R896 B7ZC38 Q9NR46	B1AMU3 Q9Y3B2
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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