LTB4R2 and PKD1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		LTB4R2	PKD1
Description		leukotriene B4 receptor 2	polycystin 1, transient receptor potential channel interacting
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Cation Channel Complex Calcium Channel Complex Ciliary Membrane Extracellular Exosome
	Molecular Function	Leukotriene B4 Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt-activated Receptor Activity Transmembrane Transporter Binding
	Biological Process	Chemotaxis Inflammatory Response Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Response To Fluid Shear Stress Lymph Vessel Morphogenesis Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Signaling By Wnt Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Leukotriene receptors G alpha (q) signalling events	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs		Amelubant Leukotriene B4
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196)	Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		48 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MUC1 MYO1E OBSL1 P4HTM PER1 PIGM PKD1 PTGIS RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	39 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DDX58 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NADSYN1 NCF1 NCK2 NTHL1 NTN3 OR1F1 PDPK1 PIP5K1C PKD2 PPL PTK2 PTPRG PXN RGS7 RPL3L SIAH1 SOX17 SRC TLN1 VCL VIM
Entrez ID		56413	5310
HPRD ID		16153	03203
Ensembl ID		ENSG00000213906	ENSG00000008710
Uniprot IDs		B4E292 Q9NPC1	P98161
PDB IDs			1B4R 6A70
Enriched GO Terms of Interacting Partners?
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