PRL and PRLR

Number of citations of the paper that reports this interaction (PubMedID 9626554)
286

Data Source:
HPRD (in vivo, in vitro)

		PRL	PRLR
Description		prolactin	prolactin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex
	Molecular Function	Prolactin Receptor Binding Hormone Activity Protein Binding	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Prolactin Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Regulation Of Multicellular Organism Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Lactation	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Prolactin Signaling Pathway Oncostatin-M-mediated Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Leukemia Inhibitory Factor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Obesity ( 19151714) Paget's disease ( 21623375) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278)	Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		5 interacting genes: MEOX2 PPIB PRLR SCARB1 UBQLN4	22 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 ICAM3 INSIG2 JAK2 MFGE8 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		5617	5618
HPRD ID		07180	01457
Ensembl ID		ENSG00000172179	ENSG00000113494
Uniprot IDs		P01236 Q5I0G2 Q5THQ0	P16471
PDB IDs		1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ	1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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