PRL and PPIB

Number of citations of the paper that reports this interaction (PubMedID 10935542)
28

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PRL	PPIB
Description		prolactin	peptidylprolyl isomerase B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Prolactin Receptor Binding Hormone Activity Protein Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Unfolded Protein Binding RNA Polymerase Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Regulation Of Multicellular Organism Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Lactation	Protein Peptidyl-prolyl Isomerization Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Positive Regulation By Host Of Viral Process Positive Regulation By Host Of Viral Genome Replication Protein Stabilization Bone Development Chaperone-mediated Protein Folding Regulation Of Post-translational Protein Modification
Pathways		Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling	Collagen biosynthesis and modifying enzymes
Drugs			Proline 1,4-Dithiothreitol
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Obesity ( 19151714) Paget's disease ( 21623375) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: MEOX2 PPIB PRLR SCARB1 UBQLN4	24 interacting genes: APOB ATP12A BANP CAMLG DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB SMAD6 STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1
Entrez ID		5617	5479
HPRD ID		07180	00458
Ensembl ID		ENSG00000172179	ENSG00000166794
Uniprot IDs		P01236 Q5I0G2 Q5THQ0	P23284
PDB IDs		1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ	1CYN 3ICH 3ICI
Enriched GO Terms of Interacting Partners?
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