PPIB and SMAD6

		PPIB	SMAD6
Description		peptidylprolyl isomerase B	SMAD family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Protein-containing Complex Heteromeric SMAD Protein Complex
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Unfolded Protein Binding RNA Polymerase Binding	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Positive Regulation By Host Of Viral Process Positive Regulation By Host Of Viral Genome Replication Protein Stabilization Bone Development Chaperone-mediated Protein Folding Regulation Of Post-translational Protein Modification	Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Negative Regulation Of SMAD Protein Complex Assembly Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Collagen biosynthesis and modifying enzymes	Signaling by BMP RUNX2 regulates bone development
Drugs		Proline 1,4-Dithiothreitol
Diseases
GWAS			Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lung cancer (smoking interaction) ( 24658283) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		24 interacting genes: APOB ATP12A BANP CAMLG DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB SMAD6 STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1	24 interacting genes: ANXA2 BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 MYO1E PIGB PIK3R4 PPIB RAB11A RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1 UACA
Entrez ID		5479	4091
HPRD ID		00458	04240
Ensembl ID		ENSG00000166794	ENSG00000137834
Uniprot IDs		P23284	O43541
PDB IDs		1CYN 3ICH 3ICI
Enriched GO Terms of Interacting Partners?
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