THAP12 and STK4

Number of citations of the paper that reports this interaction (PubMedID 24255178)
195

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		THAP12	STK4
Description		THAP domain containing 12	serine/threonine kinase 4
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Protein Tetramerization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)	Bipolar disorder ( 33263727 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		10 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 STK4 TACC1 TP53 ZNF526	29 interacting genes: AKT1 APOBEC3C CASP3 CNKSR1 CSN1S1 DAPK2 DAXX DDIT4L EMILIN3 EPPK1 H2BC21 IL2RG KEAP1 LATS1 MAFB MAP1LC3B MARK2 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 THAP12 TP53
Entrez ID		5612	6789
HPRD ID		09567	05395
Ensembl ID		ENSG00000137492	ENSG00000101109
Uniprot IDs		A0A140VJQ7 O43422	Q13043
PDB IDs			2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT
Enriched GO Terms of Interacting Partners?
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