STK4 and SAV1

Number of citations of the paper that reports this interaction (PubMedID 16930133)
104

Data Source:
HPRD (in vitro, in vivo)

		STK4	SAV1
Description		serine/threonine kinase 4	salvador family WW domain containing protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Dendrite
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	Protein Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding Identical Protein Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Protein Tetramerization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Hair Follicle Development Apoptotic Process Signal Transduction Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Population Maintenance
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs
Diseases
GWAS		Bipolar disorder ( 33263727 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		29 interacting genes: AKT1 APOBEC3C CASP3 CNKSR1 CSN1S1 DAPK2 DAXX DDIT4L EMILIN3 EPPK1 H2BC21 IL2RG KEAP1 LATS1 MAFB MAP1LC3B MARK2 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 THAP12 TP53	5 interacting genes: EP300 NEDD4 POLE2 STK3 STK4
Entrez ID		6789	60485
HPRD ID		05395	06229
Ensembl ID		ENSG00000101109	ENSG00000151748
Uniprot IDs		Q13043	B3KTQ1 Q9H4B6
PDB IDs		2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT	6AO5
Enriched GO Terms of Interacting Partners?
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