PRKAA2 and RPTOR

  • Number of citations of the paper that reports this interaction (PubMedID 18439900)
  • 1439
  • Data Source:
  • BioGRID (enzymatic study)

PRKAA2

RPTOR

Description protein kinase AMP-activated catalytic subunit alpha 2 regulatory associated protein of MTOR complex 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Bipolar disorder ( 31043756)
  • Body mass index ( 28892062 25673413)
  • Body size at age 10 ( 32376654)
  • Hypertension ( 30487518)
  • Mean arterial pressure ( 30487518)
  • NASH resolution in nonalcoholic steatohepatitis ( 31832568)
  • Nicotine dependence symptom count ( 25555482)
  • Obesity ( 23563607)
  • Pulse pressure ( 29403010 30487518)
  • Systolic blood pressure ( 30487518)
Interacting Genes 122 interacting genes: ABI1 ABI2 ACACA ACACB AIMP2 AKAP8L AMOT AMOTL2 ANAPC11 APPBP2 ARRDC3 AVPI1 C19orf47 CALCOCO1 CALCOCO2 CCDC172 CCDC33 CCNB1IP1 CDC42EP1 CDR2 CDX4 CPSF7 CTAG2 CYSRT1 DNAAF6 DNM2 DNMT1 DVL3 EEF2K EMILIN1 EPM2A EPN2 FNDC3B FOS GIGYF1 GLI1 GOLGA2 GOLGA6A GRAP2 HAT1 HMBOX1 HNF4A HOMEZ IKZF1 IKZF3 KCTD1 KCTD9 KIAA1328 KIF16B KIF24 KIFC3 KRT16 KRT31 KRTAP1-3 KRTAP10-3 KRTAP10-9 L3MBTL3 LCN2 LEP LZTS2 MKRN3 MORN3 MRFAP1 MTUS2 MYCL MYOZ1 NAB2 NECAB2 NONO NOTCH2NLA NRAP NRBF2 NUTM1 PBXIP1 PFKFB2 PLEKHN1 PPP1R32 PRDM6 PRKAB1 PRKAG1 PRKAR1B PRKN PRPH RASAL3 RBBP7 RBPMS REL RFX6 RPTOR SERTAD3 SKIV2L SLA2 SNW1 SOHLH1 SPRY1 STAC2 STK11 TCF4 TFAP2A TIFA TLE5 TMOD1 TRIP13 TRIP6 TSC22D4 UBE2I USH1C USH1G USHBP1 USP10 VPS28 VPS37B VPS52 WASHC1 WWP1 WWP2 YPEL3 ZBTB8A ZMYND12 ZNF212 ZNF397 ZSCAN23 30 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2
Entrez ID 5563 57521
HPRD ID 02735 06184
Ensembl ID ENSG00000162409 ENSG00000141564
Uniprot IDs P54646 Q6DKI0 Q8N122
PDB IDs 2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6 5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
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