AMBRA1 and BECN1

  • Number of citations of the paper that reports this interaction (PubMedID 17589504)
  • 394
  • Data Source:
  • HPRD (two hybrid, in vivo, in vitro)

AMBRA1

BECN1

Description autophagy and beclin 1 regulator 1 beclin 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Body mass index ( 28552196)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597)
  • Immunoglobulin A ( 20694011)
  • Insulin-related traits (multivariate analysis) ( 32002517)
  • Normal facial asymmetry (angle of deformation score) ( 30631343)
  • Schizophrenia ( 28991256 29483656 30285260)
  • Selective IgA deficiency ( 27723758)
  • Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes 20 interacting genes: ALX4 BECN1 CHUK CREM CUL4B GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBE2D3 57 interacting genes: AKT1 AMBRA1 ARAF ARNT BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 ITCH ITPR1 ITPR3 KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NXF1 PDGFRA PGK1 RACK1 RAF1 SENP3 SGF29 SHD SMAD2 STK11 STYK1 TEAD2 TERT TSC1 UBC ULK1 WASHC1 XPO1 YES1
Entrez ID 55626 8678
HPRD ID 10975 05087
Ensembl ID ENSG00000110497 ENSG00000126581
Uniprot IDs A0A075B6T1 Q9C0C7 A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4
PDB IDs 2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK 7BL1
Enriched GO Terms of Interacting Partners?
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