AMBRA1 and CUL4B

Number of citations of the paper that reports this interaction (PubMedID 31973889)
8

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		AMBRA1	CUL4B
Description		autophagy and beclin 1 regulator 1	cullin 4B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Nervous System Development Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Histone H2A Monoubiquitination Ribosome Biogenesis UV-damage Excision Repair
Pathways		Macroautophagy	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)
Interacting Genes		20 interacting genes: ALX4 BECN1 CHUK CREM CUL4B GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBE2D3	55 interacting genes: AHR AMBRA1 APP AR BRWD1 BRWD3 CAND1 COMMD1 COP1 COPS2 COPS5 CRBN CUL4A DCAF10 DCAF11 DCAF12 DCAF15 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCUN1D1 DCUN1D4 DDA1 DDB1 DDB2 DET1 DNMT3B DTL ERCC8 ESR1 GLMN HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PHIP PLS3 PRDX3 PTEN PWP1 RBX1 RNF7 SALL2 SIN3A SRC ST7 TBL3 TRPC4AP UBC UBE2D3 WDTC1 ZMAT4
Entrez ID		55626	8450
HPRD ID		10975	02251
Ensembl ID		ENSG00000110497	ENSG00000158290
Uniprot IDs		A0A075B6T1 Q9C0C7	K4DI93 Q13620
PDB IDs			2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?
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