CUL4B and DET1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CUL4B	DET1
Description		cullin 4B	DET1 partner of COP1 E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Histone H2A Monoubiquitination Ribosome Biogenesis UV-damage Excision Repair	Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Assembly
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Menarche (age at onset) ( 25231870) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		55 interacting genes: AHR AMBRA1 APP AR BRWD1 BRWD3 CAND1 COMMD1 COP1 COPS2 COPS5 CRBN CUL4A DCAF10 DCAF11 DCAF12 DCAF15 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCUN1D1 DCUN1D4 DDA1 DDB1 DDB2 DET1 DNMT3B DTL ERCC8 ESR1 GLMN HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PHIP PLS3 PRDX3 PTEN PWP1 RBX1 RNF7 SALL2 SIN3A SRC ST7 TBL3 TRPC4AP UBC UBE2D3 WDTC1 ZMAT4	3 interacting genes: COP1 CUL4B DDB1
Entrez ID		8450	55070
HPRD ID		02251	13140
Ensembl ID		ENSG00000158290	ENSG00000140543
Uniprot IDs		K4DI93 Q13620	A0A024RC56 Q7L5Y6
PDB IDs		2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?
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