ATG16L1 and GAN

Number of citations of the paper that reports this interaction (PubMedID 30770803)
15

Data Source:
BioGRID (protein complementation assay)

		ATG16L1	GAN
Description		autophagy related 16 like 1	gigaxonin
Image
GO Annotations	Cellular Component	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane Vacuole-isolation Membrane Contact Site	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding	Molecular_function Protein Binding
	Biological Process	Autophagosome Assembly Positive Regulation Of Autophagy Protein Transport Macroautophagy Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Protein Lipidation Involved In Autophagosome Assembly Xenophagy	Cytoskeleton Organization Protein Ubiquitination
Pathways		Macroautophagy Macroautophagy	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)	Age-related cataracts ( 25352737) Health literacy ( 31250787) Post bronchodilator FEV1 ( 26634245) Skin and soft tissue infections ( 33662382) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN GIGYF2 NOD1 NOD2 OPTN PLD3 RAB33A RAB33B SCAP SETD7 TRAF3IP3 ZFP36	5 interacting genes: ATG16L1 IRF8 MAP1B TBCB UBA1
Entrez ID		55054	8139
HPRD ID		16498	05647
Ensembl ID		ENSG00000085978	ENSG00000261609
Uniprot IDs		A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5	A0A0S2Z4W2 B3KTC3 Q9H2C0
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX	2PPI 3HVE
Enriched GO Terms of Interacting Partners?
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