ATG16L1 and DEDD2

Number of citations of the paper that reports this interaction (PubMedID 27273576)
26

Data Source:
BioGRID (pull down)

		ATG16L1	DEDD2
Description		autophagy related 16 like 1	death effector domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane Vacuole-isolation Membrane Contact Site	Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding	DNA Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Autophagosome Assembly Positive Regulation Of Autophagy Protein Transport Macroautophagy Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Protein Lipidation Involved In Autophagosome Assembly Xenophagy	RNA Processing Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Macroautophagy Macroautophagy
Drugs
Diseases
GWAS		Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)	Meat-related diet ( 32066663)
Interacting Genes		18 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN GIGYF2 NOD1 NOD2 OPTN PLD3 RAB33A RAB33B SCAP SETD7 TRAF3IP3 ZFP36	12 interacting genes: ATG16L1 CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2
Entrez ID		55054	162989
HPRD ID		16498	10868
Ensembl ID		ENSG00000085978	ENSG00000160570
Uniprot IDs		A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5	Q8WXF8
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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