ATG16L1 and NOD1

Number of citations of the paper that reports this interaction (PubMedID 19898471)
501

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ATG16L1	NOD1
Description		autophagy related 16 like 1	nucleotide binding oligomerization domain containing 1
Image
GO Annotations	Cellular Component	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane Vacuole-isolation Membrane Contact Site	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane Phagocytic Vesicle Anchored Component Of Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding
	Biological Process	Autophagosome Assembly Positive Regulation Of Autophagy Protein Transport Macroautophagy Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Protein Lipidation Involved In Autophagosome Assembly Xenophagy	Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Positive Regulation Of Cell Death Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Muramyl Dipeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Xenophagy
Pathways		Macroautophagy Macroautophagy	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs
Diseases
GWAS		Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Knee osteoarthritis ( 27696742) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		18 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN GIGYF2 NOD1 NOD2 OPTN PLD3 RAB33A RAB33B SCAP SETD7 TRAF3IP3 ZFP36	13 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP
Entrez ID		55054	10392
HPRD ID		16498	05815
Ensembl ID		ENSG00000085978	ENSG00000106100
Uniprot IDs		A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5	A0A024RA73 G3XAL1 Q9Y239
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX	2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW
Enriched GO Terms of Interacting Partners?
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