VPS13C and RAB8B

		VPS13C	RAB8B
Description		vacuolar protein sorting 13 homolog C	RAB8B, member RAS oncogene family
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol Extrinsic Component Of Membrane Dense Core Granule Membrane Extracellular Exosome	Nucleoplasm Endosome Peroxisomal Membrane Plasma Membrane Synaptic Vesicle Nuclear Body Trans-Golgi Network Transport Vesicle Phagocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Cell Tip Recycling Endosome Membrane Extracellular Exosome
	Molecular Function		GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding GDP Binding TPR Domain Binding
	Biological Process	Protein Targeting To Vacuole Golgi To Endosome Transport Mitochondrion Organization Response To Insulin Protein Retention In Golgi Apparatus Negative Regulation Of Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization	Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Cell Projection Organization Cellular Response To Insulin Stimulus Protein Import Into Peroxisome Membrane Golgi Vesicle Fusion To Target Membrane Positive Regulation Of Corticotropin Secretion Cilium Assembly Protein Localization To Plasma Membrane Cell-substrate Junction Organization
Pathways			TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs			Phosphoaminophosphonic acid guanylate ester Guanosine-5'-Diphosphate
Diseases
GWAS		Asthma ( 29273806) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Body mass index ( 28892062) Breast size ( 27182965) Cataracts ( 34127677) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Insular cortex volume ( 31530798) Intraocular pressure ( 29785010 31959993 30054594) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Proinsulin levels ( 21873549) Schizophrenia ( 28991256 29483656) Triglyceride levels ( 32203549) Tuberculosis susceptibility in HIV infection ( 26942285) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857)	Refractive error ( 32231278) Serum metabolite levels ( 23093944) Social communication problems ( 24564958)
Interacting Genes		2 interacting genes: LDHAL6B RAB8B	8 interacting genes: APP CDH1 RAB3IP RALA TUBA4A TUBB VIM VPS13C
Entrez ID		54832	51762
HPRD ID		12323	11476
Ensembl ID		ENSG00000129003	ENSG00000166128
Uniprot IDs		Q709C8	Q92930
PDB IDs
Enriched GO Terms of Interacting Partners?
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