POLE2 and PARK7

POLE2

PARK7

Description DNA polymerase epsilon 2, accessory subunit Parkinsonism associated deglycase
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Behcet's disease ( 33393726)
  • Blood protein levels ( 30072576)
  • Celiac disease ( 20190752)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 28067908)
  • Inflammatory bowel disease ( 28067908)
  • Ischemic stroke ( 24262325)
  • Ulcerative colitis ( 28067908 21297633)
Interacting Genes 25 interacting genes: AGFG1 ATOH1 BAIAP2L2 DRD3 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 NID2 PARK7 PKM POLE POLE4 PYGL REL SAP18 SAV1 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620 26 interacting genes: BAX BBS1 BCL2L1 CASP8 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 NDUFA4 PIAS2 PINK1 POLE2 PPP2R1A PPP2R1B PRKACA SNCA SOD1 SUMO1 UBA2 UBE2I
Entrez ID 5427 11315
HPRD ID 16007 03961
Ensembl ID ENSG00000100479 ENSG00000116288
Uniprot IDs P56282 Q99497 V9HWC2
PDB IDs 2V6Z 5VBN 1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z 7C62
Enriched GO Terms of Interacting Partners?
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