POLE2 and PYGL

		POLE2	PYGL
Description		DNA polymerase epsilon 2, accessory subunit	glycogen phosphorylase L
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GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Purine Nucleobase Binding Protein Binding ATP Binding Glucose Binding Glycogen Phosphorylase Activity AMP Binding Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding Linear Malto-oligosaccharide Phosphorylase Activity SHG Alpha-glucan Phosphorylase Activity
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Repair Error-prone Translesion Synthesis	Glycogen Metabolic Process Glycogen Catabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Response To Bacterium Glucose Homeostasis Necroptotic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Cladribine
Diseases
GWAS		Trigger finger ( 32740585)	Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 30072576 29875488) Psychosis (atypical) ( 24132900) Rectal cancer ( 33632709)
Interacting Genes		25 interacting genes: AGFG1 ATOH1 BAIAP2L2 DRD3 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 NID2 PARK7 PKM POLE POLE4 PYGL REL SAP18 SAV1 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	7 interacting genes: BAG1 HSD17B10 HSD3B7 IDH2 POLE2 PYGB PYGM
Entrez ID		5427	5836
HPRD ID		16007	01987
Ensembl ID		ENSG00000100479	ENSG00000100504
Uniprot IDs		P56282	P06737
PDB IDs		2V6Z 5VBN	1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW
Enriched GO Terms of Interacting Partners?
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