LURAP1 and DOCK10

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LURAP1	DOCK10
Description		leucine rich adaptor protein 1	dedicator of cytokinesis 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actomyosin Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Dendritic Spine Extracellular Exosome
	Molecular Function	Protein Binding	Molecular_function Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Cell Migration Actomyosin Structure Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase Mediated Signal Transduction Regulation Of Cell Migration Positive Regulation Of GTPase Activity Dendritic Spine Morphogenesis
Pathways			CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Granulocyte percentage of myeloid white cells ( 27863252) IgE levels in asthmatics (D.p. specific) ( 23967269) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Response to bupropion and depression ( 27622933) Response to exercise (triglyceride level interaction) ( 26491034) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		22 interacting genes: ABI2 AMOT BLOC1S6 CCDC112 CCDC185 CSNK1D DOCK10 DTNB HAUS1 HGS HMG20A KRT3 PRPF31 SHFL SNAP29 TCEANC THAP7 TPM3 TXLNB U2AF2 ZNF417 ZNF821	4 interacting genes: CCDC102B LURAP1 MAGEA11 RHOJ
Entrez ID		541468	55619
HPRD ID		18478	10919
Ensembl ID		ENSG00000171357	ENSG00000135905
Uniprot IDs		Q96LR2	Q96BY6
PDB IDs			6TKY 6TKZ 6TM1
Enriched GO Terms of Interacting Partners?
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