PMM2 and ACY3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PMM2	ACY3
Description		phosphomannomutase 2	aminoacylase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuronal Cell Body	Cytosol Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Phosphomannomutase Activity Protein Binding Metal Ion Binding	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding
	Biological Process	Mannose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation GDP-mannose Biosynthetic Process	Biological_process
Pathways		Defective PMM2 causes PMM2-CDG (CDG-1a) Synthesis of GDP-mannose	Aflatoxin activation and detoxification
Drugs
Diseases
GWAS		Glaucoma (high intraocular pressure) ( 25173107)	Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: ACY3 MEOX2 SGK2 ZC3H7A	21 interacting genes: AAMDC ARF5 ASPA CYSRT1 DDIT4L GORASP2 INCA1 KRTAP10-3 KRTAP10-8 KRTAP15-1 KRTAP26-1 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 PTGER4 RARG RRAS
Entrez ID		5373	91703
HPRD ID		03472	12422
Ensembl ID		ENSG00000140650	ENSG00000132744
Uniprot IDs		A0A0S2Z4J6 O15305 Q59F02	A0A024R5L2 Q96HD9
PDB IDs		2AMY 2Q4R
Enriched GO Terms of Interacting Partners?
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