PMCH and PCSK1

Number of citations of the paper that reports this interaction (PubMedID 10037747)
8

Data Source:
HPRD (in vivo)

		PMCH	PCSK1
Description		pro-melanin concentrating hormone	proprotein convertase subtilisin/kexin type 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Synapse	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection
	Molecular Function	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding	Serine-type Endopeptidase Activity Identical Protein Binding
	Biological Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Behavior Feeding Behavior Cell Differentiation	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs			Insulin pork
Diseases
GWAS		Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)	Adult body size ( 32376654) Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Body mass index and fasting glucose (pairwise) ( 33619380) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)
Interacting Genes		10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	5 interacting genes: FER IAPP PCSK1N PMCH REN
Entrez ID		5367	5122
HPRD ID		01459	01201
Ensembl ID		ENSG00000183395	ENSG00000175426
Uniprot IDs		P20382	P29120
PDB IDs
Enriched GO Terms of Interacting Partners?
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