PMCH and PCSK6

Number of citations of the paper that reports this interaction (PubMedID 10037747)
8

Data Source:
HPRD (in vivo, in vitro)

		PMCH	PCSK6
Description		pro-melanin concentrating hormone	proprotein convertase subtilisin/kexin type 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding
	Biological Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Behavior Feeding Behavior Cell Differentiation	Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	12 interacting genes: ALPL CACNA1A FLG FN3K IGF1R IL16 PCSK5 PMCH RCN3 SNRPA1 SYNM ZNF441
Entrez ID		5367	5046
HPRD ID		01459	01329
Ensembl ID		ENSG00000183395	ENSG00000140479
Uniprot IDs		P20382	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs
Enriched GO Terms of Interacting Partners?
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