ATP6V0A1 and HRH1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		ATP6V0A1	HRH1
Description		ATPase H+ transporting V0 subunit a1	histamine receptor H1
Image
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Integral Component Of Membrane Vacuolar Proton-transporting V-type ATPase Complex Nuclear Speck Secretory Granule Membrane Phagocytic Vesicle Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity ATPase Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Vacuolar Acidification Regulation Of Macroautophagy Toxin Transport Proton Transmembrane Transport	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Memory Visual Learning Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Regulation Of Vascular Permeability Positive Regulation Of Vasoconstriction Inositol Phosphate-mediated Signaling Regulation Of Synaptic Plasticity Eosinophil Chemotaxis Cellular Response To Histamine G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport	Histamine receptors G alpha (q) signalling events
Drugs		Tiludronic acid	Citalopram Benzatropine Ziprasidone Clemastine Amitriptyline Olanzapine Cetirizine Terfenadine Buclizine Clozapine Doxylamine Mirtazapine Dexbrompheniramine Loxapine Promazine Triprolidine Prochlorperazine Cyproheptadine Loratadine Imipramine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Hydroxyzine Cinnarizine Astemizole Trazodone Paroxetine Azatadine Trimipramine Risperidone Meclizine Carbinoxamine Epinastine Benzquinamide Olopatadine Propiomazine Tripelennamine Tolazoline Brompheniramine Methdilazine Ketotifen Maprotiline Fexofenadine Desloratadine Azelastine Dimenhydrinate Promethazine Mequitazine Diphenhydramine Emedastine Levocabastine Chlorpheniramine Doxepin Diphenylpyraline Desipramine Orphenadrine Escitalopram Cyclizine Quetiapine Bromodiphenhydramine Aripiprazole Chlorprothixene Alimemazine Paliperidone Methotrimeprazine Aceprometazine Phenindamine Pheniramine Zuclopenthixol Clofedanol Flunarizine Bepotastine Tesmilifene Iloperidone HY10275 OBE101 SO-101 Histamine Epicept NP-1 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Levocetirizine Esmirtazapine Mepyramine Betahistine Alcaftadine Antazoline Chloropyramine Dimetindene Isothipendyl Perospirone Chlorcyclizine Butriptyline Dosulepin Lorpiprazole Acrivastine Dexchlorpheniramine maleate Thonzylamine Bilastine Rupatadine Aripiprazole lauroxil
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Mortality in sepsis ( 27639821) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 27618447 27618452)
Interacting Genes		7 interacting genes: ABLIM2 CLIC1 CYTH2 HRH1 SEH1L SNX4 ZNF267	13 interacting genes: ADGRA3 ATP6V0A1 BBS5 CD81 CNBP DHRS7 LIMS2 MAT2B NAB2 SLC35B1 SLC43A2 WLS YIPF3
Entrez ID		535	3269
HPRD ID		01886	02544
Ensembl ID		ENSG00000033627	ENSG00000196639
Uniprot IDs		Q53ET5 Q53X12 Q5CZH6 Q93050	P35367
PDB IDs		6WLW 6WM2 6WM3 6WM4	3RZE
Enriched GO Terms of Interacting Partners?
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