PLAUR and LRP1B

Number of citations of the paper that reports this interaction (PubMedID 11384978)
43

Data Source:
HPRD (in vivo)

		PLAUR	LRP1B
Description		plasminogen activator, urokinase receptor	LDL receptor related protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Specific Granule Membrane Cell Projection	Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Receptor-mediated Endocytosis Protein Transport
Pathways		Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Alteplase Urokinase Tenecteplase WX-UK1 Lanoteplase
Diseases
GWAS		Basophil count ( 32888494) Blood protein levels ( 29875488) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Aging ( 19367585) Asthma (childhood onset) ( 27611488) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413 20935630) Body size at age 10 ( 32376654) Cataracts ( 34127677) Cerebellum white matter volume ( 31530798) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive performance (processing speed) ( 31598132) Congenital heart disease (inherited effect) ( 28468790) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dietary fat liking ( 32516399) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31217584) Facial attractiveness (male raters) ( 30946739) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate in chronic kidney disease ( 26420894) Hepcidin/ferritin ratio ( 27846281) Household income (MTAG) ( 31844048) Influenza A (H1N1) infection ( 26379185) Keratoconus ( 33649486) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 21102462 25231870) Mood instability ( 31168069) Motion sickness ( 25628336) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Optic nerve measurement (disc area) ( 20395239) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Periodontitis (CDC/AAP) ( 24024966) Post bronchodilator FEV1 ( 26634245) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Severe influenza A (H1N1) infection ( 26379185) Type 1 diabetes ( 32005708) Type 2 diabetes ( 30130595)
Interacting Genes		21 interacting genes: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PDGFRB PFN2 PLAU SRPX2 SURF2 TYK2 VTN	8 interacting genes: APP EVL FGA LRPAP1 PABPC1 PLAT PLAUR SERPINE1
Entrez ID		5329	53353
HPRD ID		01421	16383
Ensembl ID		ENSG00000011422	ENSG00000168702
Uniprot IDs		M0R1I2 Q03405	Q9NZR2
PDB IDs		1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI
Enriched GO Terms of Interacting Partners?
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