PLAUR and IL6ST

Number of citations of the paper that reports this interaction (PubMedID 9353320)
23

Data Source:
HPRD (in vitro)

		PLAUR	IL6ST
Description		plasminogen activator, urokinase receptor	interleukin 6 cytokine family signal transducer
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Specific Granule Membrane Cell Projection	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Membrane Raft Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Identical Protein Binding Interleukin-27 Receptor Activity Scaffold Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Platelet Aggregation
Pathways		Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot	Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs		Alteplase Urokinase Tenecteplase WX-UK1 Lanoteplase
Diseases
GWAS		Basophil count ( 32888494) Blood protein levels ( 29875488) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 34127860)
Interacting Genes		21 interacting genes: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PDGFRB PFN2 PLAU SRPX2 SURF2 TYK2 VTN	35 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 FBXO2 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		5329	3572
HPRD ID		01421	02824
Ensembl ID		ENSG00000011422	ENSG00000134352
Uniprot IDs		M0R1I2 Q03405	A0A0A0N0L2 P40189 Q17RA0
PDB IDs		1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI	1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?
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