PGGT1B and RRAS2

Number of citations of the paper that reports this interaction (PubMedID 15451670)
91

Data Source:
HPRD (in vitro)

		PGGT1B	RRAS2
Description		protein geranylgeranyltransferase type I subunit beta	RAS related 2
Image		No pdb structure
GO Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small Molecule Binding Peptide Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Protein Prenylation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways			RND1 GTPase cycle
Drugs		L-778123 Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS		Longevity ( 30294719)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2	32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		5229	22800
HPRD ID		03612	02518
Ensembl ID		ENSG00000164219	ENSG00000133818
Uniprot IDs		P53609	P62070
PDB IDs			2ERY
Enriched GO Terms of Interacting Partners?
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