RRAS2 and RASSF5

Number of citations of the paper that reports this interaction (PubMedID 11857081)
66

Data Source:
HPRD (in vitro)

		RRAS2	RASSF5
Description		RAS related 2	Ras association domain family member 5
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Nucleus Cytoplasm Microtubule
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Nucleus
Pathways		RND1 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Inflammatory bowel disease ( 23128233) Late-onset Alzheimer's disease ( 27770636) Neurofibrillary tangles ( 25188341)
Interacting Genes		32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	30 interacting genes: ADH6 AMOTL2 APPBP2 BTRC HRAS KRAS KRT40 KRTAP4-2 LSM7 MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 UBQLN2 VPS28
Entrez ID		22800	83593
HPRD ID		02518	06117
Ensembl ID		ENSG00000133818	ENSG00000266094
Uniprot IDs		P62070	A8K5F3 Q8WWW0
PDB IDs		2ERY	4LGD 4OH8
Enriched GO Terms of Interacting Partners?
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