IER3IP1 and CERS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IER3IP1	CERS4
Description		immediate early response 3 interacting protein 1	ceramide synthase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle Integral Component Of Golgi Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Positive Regulation Of Extracellular Matrix Constituent Secretion Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Brain Development Protein Transport Organ Growth Positive Regulation Of Protein Secretion Regulation Of Fibroblast Apoptotic Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Fruit consumption ( 32066663)	Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		43 interacting genes: AIG1 C19orf18 CDIPT CERS2 CERS4 CSNK2B CST1 DPM3 EBP ELOVL4 ERMP1 FAM210B FCER1G GJB1 GOSR2 GPR42 HERPUD2 JAGN1 KCNA1 MOSPD3 PEX12 PIGP PLP1 POMK RGS2 SCN3B SLC30A4 TK1 TM4SF18 TMEM128 TMEM14A TMEM14B TMEM167A TMEM237 TMEM258 TMEM80 TMEM86B TMPPE TMX2 TRHR UBQLN1 YIPF4 ZFYVE27	47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		51124	79603
HPRD ID		13727	13962
Ensembl ID		ENSG00000134049	ENSG00000090661
Uniprot IDs		Q9Y5U9	Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?
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