GLRX2 and TXNRD1

Number of citations of the paper that reports this interaction (PubMedID 14676218)
77

Data Source:
HPRD (in vitro)

		GLRX2	TXNRD1
Description		glutaredoxin 2	thioredoxin reductase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body Intracellular Membrane-bounded Organelle	Fibrillar Center Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding Glutathione Oxidoreductase Activity	Thioredoxin-disulfide Reductase Activity Protein Binding Flavin Adenine Dinucleotide Binding Glutathione Oxidoreductase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Glutathione Metabolic Process Apoptotic Process Aging Response To Temperature Stimulus Regulation Of Signal Transduction Response To Organic Substance Electron Transport Chain Cell Differentiation DNA Protection Response To Hydrogen Peroxide Cell Redox Homeostasis Response To Redox State Cellular Response To Superoxide	Mesoderm Formation Signal Transduction Cell Population Proliferation Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways			PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes
Drugs		Glutathione	Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12
Diseases
GWAS		Blood protein levels ( 29875488)	Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)
Interacting Genes		6 interacting genes: DCXR DENND1B ELF5 FBXO7 NUTF2 TXNRD1	11 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP
Entrez ID		51022	7296
HPRD ID		12112	03068
Ensembl ID		ENSG00000023572	ENSG00000198431
Uniprot IDs		Q9NS18	B7Z2S5 Q16881
PDB IDs		2CQ9 2FLS 2HT9	1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?
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