TXNRD1 and DMRTC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TXNRD1	DMRTC2
Description		thioredoxin reductase 1	DMRT like family C2
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Chromatin XY Body Cellular_component Nucleus
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Flavin Adenine Dinucleotide Binding Glutathione Oxidoreductase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mesoderm Formation Signal Transduction Cell Population Proliferation Cell Redox Homeostasis Cellular Oxidant Detoxification	Regulation Of Transcription By RNA Polymerase II Male Meiosis I Germ Cell Development Spermatid Nucleus Elongation Sex Differentiation Biological_process Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation
Pathways		PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes
Drugs		Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12
Diseases
GWAS		Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP	2 interacting genes: IRF9 TXNRD1
Entrez ID		7296	63946
HPRD ID		03068	16829
Ensembl ID		ENSG00000198431	ENSG00000142025
Uniprot IDs		B7Z2S5 Q16881	B4DX56 Q8IXT2
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?
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