PAPPA and TNNI3

Number of citations of the paper that reports this interaction (PubMedID 12626203)
4

Data Source:
HPRD (in vitro)

		PAPPA	TNNI3
Description		pappalysin 1	troponin I3, cardiac type
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Smooth Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Striated Muscle Contraction Ion homeostasis
Drugs		Phenethyl Isothiocyanate	N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Hip circumference adjusted for BMI ( 34021172) Intralaminar thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401)	Monocyte count ( 32888494) Platelet count ( 32888494)
Interacting Genes		11 interacting genes: ATF7IP C3 CREBBP IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		5069	7137
HPRD ID		01448	11769
Ensembl ID		ENSG00000182752	ENSG00000129991
Uniprot IDs		B4DTA8 Q13219 Q7Z613	P19429 Q6FGX2
PDB IDs			1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI
Enriched GO Terms of Interacting Partners?
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