PAPPA and SMAD9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
99

Data Source:
HPRD (two hybrid)

		PAPPA	SMAD9
Description		pappalysin 1	SMAD family member 9
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding I-SMAD Binding
	Biological Process	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid	Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation BMP Signaling Pathway SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Signaling by BMP
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Hip circumference adjusted for BMI ( 34021172) Intralaminar thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401)	Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549 28869591) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)
Interacting Genes		11 interacting genes: ATF7IP C3 CREBBP IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TTC37 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		5069	4093
HPRD ID		01448	04484
Ensembl ID		ENSG00000182752	ENSG00000120693
Uniprot IDs		B4DTA8 Q13219 Q7Z613	A0A024RDR3 O15198
PDB IDs			6FZT
Enriched GO Terms of Interacting Partners?
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