MLF1 and GRIK5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MLF1	GRIK5
Description		myeloid leukemia factor 1	glutamate ionotropic receptor kainate type subunit 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cilium Ciliary Basal Body	Nucleoplasm Endoplasmic Reticulum Plasma Membrane Dendrite Kainate Selective Glutamate Receptor Complex Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	DNA Binding Protein Binding Protein Domain Specific Binding	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Cell Cycle	Protein Retention In ER Lumen Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Establishment Of Localization In Cell Excitatory Postsynaptic Potential Cellular Response To Glucose Stimulus
Pathways			Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Major depressive disorder ( 27479909) PR interval ( 32439900) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 30224653)	Bipolar disorder ( 21771265) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte counts ( 32888494) Meat-related diet ( 32066663)
Interacting Genes		14 interacting genes: CENPU CLRN1 COP1 COPS3 DNAJB6 GBA GMPS GRIK5 MAGEA11 MEOX2 NRBP1 RARRES1 RNF13 YWHAZ	8 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		4291	2901
HPRD ID		03239	02614
Ensembl ID		ENSG00000178053	ENSG00000105737
Uniprot IDs		A0A0S2Z4U8 A0A140VKD2 B2RD48 P58340 Q2TLE4 Q5HYH4	Q16478
PDB IDs		3UAL 3UBW 6Y8E
Enriched GO Terms of Interacting Partners?
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