MCC and PCCA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MCC	PCCA
Description		MCC regulator of WNT signaling pathway	propionyl-CoA carboxylase subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity	Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Enzyme Binding Metal Ion Binding
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Short-chain Fatty Acid Catabolic Process
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism
Drugs			Biotin
Diseases
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)	Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Corpus callosum anterior volume ( 31530798) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 23396134 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		80 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CSNK1E CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 IMP3 KAT5 KIF3C KIFC3 LRRC45 MAGEE1 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 STOML2 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	4 interacting genes: ERRFI1 MCC PCCB PJA1
Entrez ID		4163	5095
HPRD ID		01157	01981
Ensembl ID		ENSG00000171444	ENSG00000175198
Uniprot IDs		P23508	P05165
PDB IDs		6MTU 6MTV	2CQY 2JKU
Enriched GO Terms of Interacting Partners?
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