MC3R and AGRP

Number of citations of the paper that reports this interaction (PubMedID 9893984)
34

Data Source:
HPRD (in vitro)

		MC3R	AGRP
Description		melanocortin 3 receptor	agouti related neuropeptide
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space Golgi Lumen Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Regulation Of Heart Rate G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Homoiothermy Locomotor Rhythm Sodium Ion Homeostasis Regulation Of Feeding Behavior	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Bremelanotide
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Metabolite levels ( 23823483)	Blood protein levels ( 30072576 29875488 28240269) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: AGRP ASIP POMC	4 interacting genes: GHRL MC3R MC4R MC5R
Entrez ID		4159	181
HPRD ID		01115	09079
Ensembl ID		ENSG00000124089	ENSG00000159723
Uniprot IDs		P41968	C6SUN5 O00253
PDB IDs			1HYK 1MR0 2IQV
Enriched GO Terms of Interacting Partners?
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