AGRP and MC5R

Number of citations of the paper that reports this interaction (PubMedID 9892020)
39

Data Source:
HPRD (in vitro)

		AGRP	MC5R
Description		agouti related neuropeptide	melanocortin 5 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Lumen Neuronal Cell Body	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Protein Binding Hormone Binding
	Biological Process	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Metabolic Process
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Bremelanotide
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)	Depression in smokers ( 30219690) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		4 interacting genes: GHRL MC3R MC4R MC5R	3 interacting genes: AGRP ASIP POMC
Entrez ID		181	4161
HPRD ID		09079	08965
Ensembl ID		ENSG00000159723	ENSG00000176136
Uniprot IDs		C6SUN5 O00253	P33032
PDB IDs		1HYK 1MR0 2IQV
Enriched GO Terms of Interacting Partners?
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