AGRP and MC3R

Number of citations of the paper that reports this interaction (PubMedID 9893984)
34

Data Source:
HPRD (in vitro)

		AGRP	MC3R
Description		agouti related neuropeptide	melanocortin 3 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Lumen Neuronal Cell Body	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior	Regulation Of Heart Rate G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Homoiothermy Locomotor Rhythm Sodium Ion Homeostasis Regulation Of Feeding Behavior
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Bremelanotide
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)	Adult body size ( 32376654) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: GHRL MC3R MC4R MC5R	3 interacting genes: AGRP ASIP POMC
Entrez ID		181	4159
HPRD ID		09079	01115
Ensembl ID		ENSG00000159723	ENSG00000124089
Uniprot IDs		C6SUN5 O00253	P41968
PDB IDs		1HYK 1MR0 2IQV
Enriched GO Terms of Interacting Partners?
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