EPCAM and TSC22D2

Number of citations of the paper that reports this interaction (PubMedID 27337956)
22

Data Source:
BioGRID (two hybrid)

		EPCAM	TSC22D2
Description		epithelial cell adhesion molecule	TSC22 domain family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Ureteric Bud Development Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Cell Motility Positive Regulation Of Stem Cell Proliferation	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress
Pathways		Cell surface interactions at the vascular wall
Drugs		Oportuzumab monatox ING-1 Catumaxomab Technetium Tc-99m nofetumomab merpentan Hypromellose
Diseases
GWAS		epithelial cell adhesion molecule levels ( 25147954)	Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30054458 30297969) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: CLDN7 TSC22D2	42 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 WNK3 ZMYM2 ZNF143 ZNF251
Entrez ID		4072	9819
HPRD ID		01709	11101
Ensembl ID		ENSG00000119888	ENSG00000196428
Uniprot IDs		P16422	B4DN36 O75157
PDB IDs		4MZV 6I07
Enriched GO Terms of Interacting Partners?
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