LSS and NUP214

		LSS	NUP214
Description		lanosterol synthase	nucleoporin 214
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore
	Molecular Function	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability	Mitotic Cell Cycle RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs		R048-8071 Lanosterol
Diseases
GWAS		White blood cell count ( 27863252)	Aspartate aminotransferase levels ( 31219225)
Interacting Genes		12 interacting genes: AQP6 CIB1 GPR35 MX2 NR4A1 NUP214 SIRT5 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	31 interacting genes: APC ASS1 CHST6 CLEC4G DDX19B DYNC1I1 IPO5 LSS MRPS6 NCBP1 NFX1 NUP107 NUP42 NUP62 NUP88 NUP98 NXF1 NXF2 POMT1 PRRX2 SMAD2 SMAD3 SMAD4 STOM SUMO2 TNPO1 VAV2 XPO1 XPO5 XPOT ZFP36
Entrez ID		4047	8021
HPRD ID		02945	00258
Ensembl ID		ENSG00000160285	ENSG00000126883
Uniprot IDs		B2R694 P48449	B7ZAV2 P35658
PDB IDs		1W6J 1W6K	2OIT 3FHC 3FMO 3FMP 5DIS
Enriched GO Terms of Interacting Partners?
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