NUP214 and ASS1

		NUP214	ASS1
Description		nucleoporin 214	argininosuccinate synthase 1
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GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore	Nucleus Cytoplasm Mitochondrial Outer Membrane Lysosome Endoplasmic Reticulum Cytosol Perikaryon Extracellular Exosome Cell Body Fiber
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development Arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Aging Response To Nutrient Circadian Rhythm Response To Xenobiotic Stimulus Response To Zinc Ion Response To Mycotoxin Response To Estradiol Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Growth Hormone Diaphragm Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Urea cycle
Drugs			Arginine Aspartic acid Aspartic acid Citrulline Citrulline ATP
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)
Interacting Genes		31 interacting genes: APC ASS1 CHST6 CLEC4G DDX19B DYNC1I1 IPO5 LSS MRPS6 NCBP1 NFX1 NUP107 NUP42 NUP62 NUP88 NUP98 NXF1 NXF2 POMT1 PRRX2 SMAD2 SMAD3 SMAD4 STOM SUMO2 TNPO1 VAV2 XPO1 XPO5 XPOT ZFP36	18 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 LINC01554 MLH1 MT2A NUP214 PMPCA PTPN1 SLC13A1 STOM SUMO2 TERF1 TERF2 USP4
Entrez ID		8021	445
HPRD ID		00258	04590
Ensembl ID		ENSG00000126883	ENSG00000130707
Uniprot IDs		B7ZAV2 P35658	P00966 Q5T6L4
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS	2NZ2
Enriched GO Terms of Interacting Partners?
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