NUP214 and NUP62

Number of citations of the paper that reports this interaction (PubMedID 26344197)
178

Data Source:
BioGRID (pull down, biochemical)

		NUP214	NUP62
Description		nucleoporin 214	nucleoporin 62
Image
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore	Spindle Pole Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Centrosome Nuclear Membrane Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Kinesin Binding Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding Protein-containing Complex Binding PTB Domain Binding Hsp90 Protein Binding
	Biological Process	Mitotic Cell Cycle RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle	RNA Export From Nucleus Protein Import Into Nucleus Mitotic Metaphase Plate Congression Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Spermatogenesis Cell Aging Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication MRNA Transport Regulation Of Mitotic Spindle Organization Centriole Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)
Interacting Genes		31 interacting genes: APC ASS1 CHST6 CLEC4G DDX19B DYNC1I1 IPO5 LSS MRPS6 NCBP1 NFX1 NUP107 NUP42 NUP62 NUP88 NUP98 NXF1 NXF2 POMT1 PRRX2 SMAD2 SMAD3 SMAD4 STOM SUMO2 TNPO1 VAV2 XPO1 XPO5 XPOT ZFP36	98 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCDC153 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 CYTH2 DDX3X DGCR6 DPPA3 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 HSPB11 IDH1 IFT20 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NAPSA NFX1 NOSIP NUP153 NUP214 NUP54 NUP58 NUP88 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PHF21A PIN1 PTMA RANBP2 SMARCA2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6 ZNF432 ZNF473 ZNF91
Entrez ID		8021	23636
HPRD ID		00258	05782
Ensembl ID		ENSG00000126883	ENSG00000213024
Uniprot IDs		B7ZAV2 P35658	A0A024QZF1 P37198
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS	2H4D 5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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