VWC2L and ATIC

		VWC2L	ATIC
Description		von Willebrand factor C domain containing 2 like	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space AMPA Glutamate Receptor Complex Synapse	Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity Cadherin Binding
	Biological Process	Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation	Brainstem Development Nucleobase-containing Compound Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Cellular Response To Interleukin-7
Pathways			Purine ribonucleoside monophosphate biosynthesis Signaling by ALK fusions and activated point mutants
Drugs			Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Degraded stimulus continuous performance test score ( 31596458) Dietary fat liking ( 32516399) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) PR interval ( 23534349)	Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ATIC C17orf50 C22orf39 CEMP1 CRCT1 CXCL5 CYSRT1 DEFB112 FBXO34 FHL3 HOXA1 KRTAP10-8 KRTAP11-1 KRTAP19-2 LCE1A LCE1C LCE3A LCE5A MEOX2 NR4A3 OTX1 PPARA RIPK4 SPATA3 TRIM42 TYRO3 YPEL3 ZNF20	11 interacting genes: CIP2A CPS1 DES EGFR LINC01554 MAP3K7 MTNR1A OGT PRNP SERPINB5 VWC2L
Entrez ID		402117	471
HPRD ID		19160	03434
Ensembl ID		ENSG00000174453	ENSG00000138363
Uniprot IDs		B2RUY7 B7ZW27	P31939 V9HWH7
PDB IDs			1P4R 1PKX 1PL0 5UY8 5UZ0
Enriched GO Terms of Interacting Partners?
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