ATIC and CPS1

		ATIC	CPS1
Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	carbamoyl-phosphate synthase 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleolus Cytoplasm Mitochondrial Inner Membrane Mitochondrial Matrix Protein-containing Complex Mitochondrial Nucleoid
	Molecular Function	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity Cadherin Binding	Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Endopeptidase Activity Calcium Ion Binding Protein Binding ATP Binding Phospholipid Binding Glutamate Binding Protein-containing Complex Binding Modified Amino Acid Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Cellular Response To Interleukin-7	Urea Cycle 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Proteolysis Glutamine Metabolic Process Nitrogen Compound Metabolic Process Midgut Development Response To Xenobiotic Stimulus Response To Toxic Substance Response To Zinc Ion Response To Amine Citrulline Biosynthetic Process Triglyceride Catabolic Process Response To Food Response To Lipopolysaccharide Vasodilation Response To Starvation Response To Amino Acid Cellular Response To Fibroblast Growth Factor Stimulus Nitric Oxide Metabolic Process Homocysteine Metabolic Process Anion Homeostasis Response To Growth Hormone Hepatocyte Differentiation Carbamoyl Phosphate Biosynthetic Process Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Response To Dexamethasone
Pathways		Purine ribonucleoside monophosphate biosynthesis Signaling by ALK fusions and activated point mutants	Urea cycle
Drugs		Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid	Carglumic acid
Diseases
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)	Acylcarnitine levels ( 26068415) Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Alzheimer's disease in APOE e4+ carriers ( 25778476) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 32203549 33730874) Appendicular lean mass ( 33097823) Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood metabolite levels ( 24816252) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 25673413) Body mass index in asthmatics ( 23517042) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462 29403010) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glycine levels ( 31070104 30837465) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Homocysteine levels ( 23824729 20154341) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte counts ( 32888494) Macular telangiectasia type 2 ( 28250457 33654266) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494 27863252) Metabolic traits ( 21886157) Metabolite levels ( 31628463 23378610) Metabolite levels (small molecules and protein measures) ( 27005778) Neutrophil count ( 32888494) Non-small cell lung cancer ( 23144319) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma homocysteine levels (post-methionine load test) ( 24651765) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Positive urgency ( 30718321) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 31636271 33031748 24625756 25569235) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 30993211) Systolic blood pressure ( 30224653) Urate levels ( 31578528) Urate levels in obese individuals ( 25811787) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407) Urinary potassium to creatinine ratio ( 30910378) Urinary sodium to creatinine ratio ( 30910378) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CIP2A CPS1 DES EGFR LINC01554 MAP3K7 MTNR1A OGT PRNP SERPINB5 VWC2L	5 interacting genes: ARAF ATIC HSD17B10 NCOA1 RAF1
Entrez ID		471	1373
HPRD ID		03434	01995
Ensembl ID		ENSG00000138363	ENSG00000021826
Uniprot IDs		P31939 V9HWH7	A0A024R454 P31327 Q6PEK7
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0	2YVQ 4UTR 4UTV 4UTX 4UTZ 4UU7 4UU8 4UUA 4UUB 5DOT 5DOU 5OJO 6UEL 6W2J
Enriched GO Terms of Interacting Partners?
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