ATIC

Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity Cadherin Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Cellular Response To Interleukin-7
Pathways		Purine ribonucleoside monophosphate biosynthesis Signaling by ALK fusions and activated point mutants
Drugs		Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
Diseases
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: CIP2A CPS1 DES EGFR LINC01554 MAP3K7 MTNR1A OGT PRNP SERPINB5 VWC2L
Entrez ID		471
HPRD ID		03434
Ensembl ID		ENSG00000138363
Uniprot IDs		P31939 V9HWH7
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0
Enriched GO Terms of Interacting Partners?
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