KPNA1 and USP1

Number of citations of the paper that reports this interaction (PubMedID 21466675)
10

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KPNA1	USP1
Description		karyopherin subunit alpha 1	ubiquitin specific peptidase 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Glutamatergic Synapse	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity
	Biological Process	Regulation Of DNA Recombination NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway	Skeletal System Development DNA Repair Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination DNA Damage Response, Detection Of DNA Damage
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production	Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		46 interacting genes: ANP32A ANP32B ARNT BCAR3 CD86 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP50 NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1	16 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K WDR48
Entrez ID		3836	7398
HPRD ID		02819	04593
Ensembl ID		ENSG00000114030	ENSG00000162607
Uniprot IDs		B3KXZ2 P52294	O94782
PDB IDs		2JDQ 3TJ3 4B18 6WX9	6DO5
Enriched GO Terms of Interacting Partners?
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